Enflurane: (Major) Halogenated anesthetics should be used cautiously and with close monitoring with ciprofloxacin. Halogenated anesthetics can prolong the QT interval. Uncommon cases of QT prolongation and torsade de pointe (TdP) have been reported with ciprofloxacin during put up-marketing surveillance. Ciprofloxacin needs to be used with warning in patients receiving medicine that prolong the QT interval.
Relugolix: (Contraindicated) Avoid concomitant use of ketoconazole and relugolix on account of an increased danger for torsade de pointes (TdP) and QT/QTc prolongation. Concomitant use may increase the exposure of relugolix, additional rising the risk for adverse effects. If concomitant use is unavoidable, administer ketoconazole not less than six hours after relugolix and monitor for opposed reactions. Alternatively, relugolix therapy may be interrupted for as much as 14 days if a brief course of ketoconazole is required; if remedy is interrupted for more than seven days, resume relugolix with a 360 mg loading dose adopted by 120 mg as soon as each day. Relugolix is a P-gp substrate and ketoconazole is a P-gp inhibitor.
Loperamide; Simethicone: (Reasonable) Concomitant use of loperamide and ciprofloxacin could enhance the danger of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Consider taking steps to minimize the danger of QT/QTc interval prolongation and TdP, such as avoidance, electrolyte monitoring and repletion, and Buy Subutex Online uk ECG monitoring, particularly in patients with additional risk elements for TdP.