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Azelastine; Fluticasone: (Reasonable) An enhanced CNS depressant impact could happen when azelastine, an antihistamine, is mixed with CNS depressants including the barbiturates. (Average) Coadministration might result in decreased exposure to fluticasone. Butalbital is a CYP3A4 inducer; fluticasone is a CYP3A4 substrate. Monitor for decreased response to fluticasone during concurrent use.
Delavirdine: (Main) Keep away from delavirdine for 2 weeks prior to and through remedy with ketoconazole. Concomitant use could increase publicity of ketoconazole and increase the risk of hostile results. If concomitant use is critical, monitor intently for ketoconazole-related adverse reactions; a ketoconazole dose discount may be necessary. Ketoconazole is a CYP3A substrate and delavirdine is a robust CYP3A inhibitor.
Donepezil; Memantine: (Contraindicated) Avoid concomitant use of ketoconazole and donepezil attributable to an increased threat for torsade de pointes (TdP) and QT/QTc prolongation. Moreover, concomitant use might improve the publicity of donepezil, additional growing the danger for adverse effects. Donepezil is a CYP3A substrate and ketoconazole is a robust CYP3A inhibitor. Coadministration with ketoconazole elevated imply donepezil concentrations by 36%.