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Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate: (Main) Advanced interactions may occur when barbiturates (e.g., phenobarbital) are administered to patients receiving treatment for HIV infection; if treating seizure disorder, a distinct anticonvulsant should be used every time attainable. If a barbiturate have to be utilized in a patient being handled for HIV, the patient have to be closely monitored for antiviral efficacy and seizure control; acceptable dose changes to the barbiturate or the antiretroviral medications are unknown. The mixture regimens used to treat HIV usually embody substrates, inducers, and inhibitors of several CYP isoenzymes. Efavirenz is a substrate and inducer of CYP3A4 and an inhibitor of CYP2C9 and CYP2C19. Phenobarbital is an inducer of CYP3A4, and a substrate and inducer of CYP2C9 and CYP2C19. Use caution if these medicine are to be coadministered, with elevated monitoring of both efavirenz and barbiturate concentrations. (Minor) Medication that induce the hepatic isoenzymes CYP2E1 and CYP1A2, reminiscent of efavirenz, could potentially enhance the chance for acetaminophen-induced hepatotoxicity through era of a greater proportion of acetaminophen’s hepatotoxic metabolite, NAPQI. Also, the analgesic activity of acetaminophen could also be diminished.