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Ranolazine: (Average) Use ranolazine with warning together with ciprofloxacin as concurrent use could improve the danger of QT prolongation. Ranolazine is related to dose- and plasma concentration-associated will increase within the QTc interval. Though there are not any studies inspecting the effects of ranolazine in patients receiving other QT prolonging medication, coadministration of such medication might lead to additive QT prolongation. Uncommon cases of QT prolongation and torsade de pointes (TdP) have been reported with ciprofloxacin during postmarketing surveillance.
Pomalidomide: (Minor) A clinically insignificant enhance in pomalidomide exposure occurred when pomalidomide and ketoconazole have been administered together in a drug interaction research. Pomalidomide is a CYP3A4 and P-glycoprotein (P-gp) substrate and ketoconazole is a strong CYP3A4 and P-gp inhibitor. In sixteen healthy male volunteers, the pomalidomide AUC worth was increased by 19% when pomalidomide was co-administered with ketoconazole.
