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Olaparib: (Major) Keep away from coadministration of olaparib with butalbital as a consequence of the risk of lowering the efficacy of olaparib. Olaparib is a CYP3A substrate and butalbital is a moderate CYP3A4 inducer; concomitant use might decrease olaparib exposure. Coadministration with a moderate CYP3A inducer is predicted to decrease the olaparib Cmax by 31% and the AUC by 60%.
Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine: (Reasonable) Administer oral ciprofloxacin no less than 2 hours earlier than or 6 hours after magnesium salicylate. Ciprofloxacin absorption could also be lowered as quinolone antibiotics can chelate with divalent or trivalent cations. (Reasonable) Reduction or limitation of the caffeine dosage in medications and limitation of caffeine in beverages and meals could also be crucial throughout concurrent ciprofloxacin therapy. Ciprofloxacin can decrease the clearance of caffeine. Caffeine toxicity might occur and may manifest as nausea, vomiting, anxiety, tachycardia, or seizures. Ciprofloxacin is a CYP1A2 inhibitor and caffeine is a CYP1A2 substrate.