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Ofloxacin: (Contraindicated) Avoid concomitant use of ketoconazole and ofloxacin as a result of an elevated threat for torsade de pointes (TdP) and QT/QTc prolongation. Ketoconazole is related to a threat for QT prolongation and TdP. Some quinolones, including ofloxacin, have been related to prolongation of the QT interval on the ECG and infrequent instances of arrhythmia. Uncommon instances ofTdP have been spontaneously reported throughout postmarketing surveillance in patients receiving quinolones, including ofloxacin.
Carbetapentane; Guaifenesin; Phenylephrine: (Average) CNS-stimulating actions of caffeine can be additive with other CNS stimulants or psychostimulants like phenylephrine; caffeine ought to be prevented or used cautiously. Extreme caffeine ingestion (by way of medicines, supplements or beverages together with coffee, dihydrocodeine 30mg po polsku green tea, other teas, guarana, colas) might contribute to side effects like nervousness, irritability, insomnia, or tremor. (Moderate) Drowsiness has been reported throughout administration of carbetapentane. An enhanced CNS depressant effect could occur when carbetapentane is mixed with different CNS depressants together with barbiturates.
Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine: (Moderate) Additive CNS depression might occur if barbiturates are co-used with sedating antihistamines, comparable to chlorpheniramine. Monitor for additive CNS and respiratory effects, and warn in regards to the potential results to driving and other actions. (Average) CNS-stimulating actions of caffeine might be additive with different CNS stimulants or psychostimulants; caffeine needs to be prevented or used cautiously. Excessive caffeine ingestion (via medicines, supplements or drinks together with coffee, inexperienced tea, different teas, guarana, colas) might contribute to uncomfortable side effects like nervousness, irritability, insomnia, or tremor.
