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Guaifenesin; Pseudoephedrine: (Reasonable) CNS-stimulating actions of caffeine will be additive with other CNS stimulants or psychostimulants; caffeine needs to be avoided or used cautiously. Excessive caffeine ingestion (via medicines, supplements or beverages including coffee, green tea, other teas, guarana, colas) might contribute to negative effects like nervousness, irritability, insomnia, or tremor.
Calcium Acetate: (Reasonable) Administer oral ciprofloxacin a minimum of 2 hours before or 6 hours after oral merchandise that comprise calcium. Ciprofloxacin absorption may be reduced as quinolone antibiotics can chelate with divalent or trivalent cations. Examples of compounds which will interfere with quinolone bioavailability embrace antacids and multivitamins that contain calcium.